The original Biloxi High School was built in 1912 on Howard Avenue. A “new” Biloxi High School was constructed in 1961 – at a cost of $1.6 million – on Father Ryan Avenue. The current Biloxi High School, hailed as a “state of the art” facility, opened in 2002, and served Grades 10, 11 and 12.

The $35 million facility, named one of the best schools in the country by the U.S. Department of Education in 2006, features a campus nestled on about 90 acres between the Back Bay of Biloxi and Interstate 10. 

This facility includes fully-equipped science laboratories; computer labs; a 200-seat lecture hall; practice and competition gymnasiums; new tennis courts; a football stadium; baseball and softball stadiums with indoor batting cages; music areas with individual practice rooms and risers; and kilns in the art classrooms.

With the 2009 school year, a $12 million expansion saw the addition of a new wing to host ninth grade students, and the addition of an internet cafe.

In the fall of 2020, the Biloxi Public School District opened a state-of-the-art, $15 million performing arts center on the Biloxi High School campus. BPAC was created to host the many performing groups and ensembles that exist within the Biloxi Public School District and to raise the level of performance experience for all of our students.